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Education clinique

Directives

2009 EANM guidelines quoting Technegas

L’Association Européenne de Médecine Nucléaire

Directives de l’EANM pour la scintigraphie de ventilation/perfusion – Part 1

Bajc M, et al. Eur J Nucl Med Mol Imaging 2009; 36: 1356-1370

Directives de l’EANM pour la scintigraphie de ventilation/perfusion – Part 2

Bajc M, et al. Eur J Nucl Med Mol Imaging 2009; 36: 1528-1538

Vidéos

Imagerie fonctionnelle des poumons avec TECHNEGASTM
Ventilation SPECT/CT avec TECHNEGASTM pour quantifier la fonction pulmonaire

Etude pulmonaire
V/Q SPECT avec TECHNEGASTM pour détecter l’embolie pulmonaire

 

Témoignages

Autres applications cliniques que l'embolie pulmonaire - résultats d'études cliniques

Évaluation de la limitation du flux d’air dans les pathologies respiratoires chroniques
Les images ont été fournies par Hunter New England Imaging (HNEI) du John Hunter Hospital et les données cliniques par le Hunter Medical Research Institute. (HMRI)

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Suivi du traitement chez les patients atteints d’asthme

Les images et données cliniques ont été fournies par le Woolcock Institute of Medical Research

 

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Évaluation de la fonction pulmonaire avant chirurgie de réduction du volume pulmonaire
Les images et les données cliniques ont été fournies respectivement par le Macquarie Medical Imaging (MMI) et le Macquarie Respiratory Sleep department de Macquarie University

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Résumé de la littérature

Edition 1 – Mai 2017
La BPCO, une nouvelle indication d’utilisation pour l’imagerie V/Q SPECT et TECHNEGASTM?

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Edition 3 – Octobre 2017
Valeur économique des caméras hybrides SPECT/CT dans le diagnostic de l’embolie pulmonaire

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Edition 2 – Aout 2017
L’imagerie V/Q SPECT/CT comme modalité de première intention pour le diagnostic de l’embolie pulmonaire?

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Edition 4 – Décembre 2018
Résumé du rapport de la Commission Lancet sur la redéfinition des maladies des voies respiratoires

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Références cliniques

Diagnosing and grading heart failure with tomographic perfusion lung scintigraphy: validation with right heart catheterization
Jögi J, et al. ESC Heart Fail 2018; 5(5): 902-910

"Although not as available as chest X-ray, V/P SPECT is a feasible alternative, especially because the introduction of SPECT and new ventilation tracers (i.e. Technegas) has lowered the number of non-diagnostic studies to <3%, even in the presence of obstructive lung disease."

CANM Guidelines for V/P SPECT in PE
Leblanc M, et al. CANM Guidelines published in November 2018

"The best widely available agent for ventilation is 99mTc-Technegas, an aerosol of carbon nanoparticles (5-200 nm) generated in a high temperature furnace (Technegas Generator, Cyclomedica). Because of the very small particle size, this agent is distributed in the lungs almost like a gas and deposited in alveoli by diffusion, where they remain stable, thus providing the best possible images for ventilation SPECT."

Lung scintigraphy in COPD
Mortensen J, et al. Semin Nucl Med 2019; 49(1): 16-21

"V/Q scintigraphy is a valuable functional imaging biomarker in relation to several aspects of COPD. Disturbances in the distribution of ventilation and perfusion, which are pertinent to the pathophysiology of COPD, are directly visualized, particularly when using inert gases or Technegas as ventilation tracers while performing the scintigraphy as SPECT."

Role of medical and molecular imaging in COPD
Myc LA, et al. Clin Transl Med 2019; 8(1): 12

"3D ventilation/perfusion SPECT imaging procedures have been used to help diagnosis. COPD patients have also been evaluated using Technegas (99mTc-labelled carbon particles). Technegas has the potential to provide valuable information for the diagnosis of COPD as it has been demonstrated to correlate positively with spirometric lung function."

SPECT Ventilation imaging in asthma
Farrow CE, et al. Semin Nucl Med 2019; 49(1): 11-15

"Technegas as a SPECT ventilation agent has a key advantage as it remains fixed after inhalation, which allows imaging of upright ventilation distribution, analogous of pulmonary function tests."

Identifying the heterogeneity of COPD by V/P SPECT: a new tool for improving the diagnosis of parenchymal defects and grading the severity of small airways disease
Bajc M, et al. Int J of Chron Obstruct Pulmon Dis 2017; 12: 1579-1587

"V/Q SPECT, using Technegas as the ventilation imaging agent, could diagnose and grade severity of COPD and also estimate preserved lung function in 94 patients. Moreover, V/Q SPECT appears to be a unique tool to reveal the heterogeneity of COPD caused by pulmonary comorbidities such as pulmonary embolism, left heart failure, lung tumor and pneumonia."

V/Q SPECT – Normal Values for Lobar Function and Comparison With CT Volumes
Bailey DL, et al. Semin Nucl Med 2019; 49(1): 58-61

"An advantage of using Technegas as the ventilation agent and radiolabelled macro-aggregated albumin microspheres as the perfusion agent is that the deposition pattern is fixed upon administration and thus different patient postures can be studied and the effect of gravity and position determined, even though the scans must be acquired with the subject supine using conventional gamma camera SPECT/CT systems"

Radionuclide diagnosis of pulmonary embolism
Hess S, et al. Adv Exp Med Biol 2017; 906: 49-65

"Technetium-99m (99mTc-Technegas) is widely available and relatively inexpensive while Xenon-133 is less than ideal for SPECT imaging owing to its relatively low energy and suboptimal spatial resolution."

Ventilation perfusion single photon emission computed tomography: Referral practices and diagnosis of acute pulmonary embolism in the quaternary clinical setting
Lawrence N, et al. J Med Imaging Radiat Oncol 2018; 62(6): 777-780

"However, the standard technique for V/Q SPECT in the US involves the use of Xenon radiotracer rather than Technegas rendering direct comparison of equivocal rates less useful."

Current status of ventilation-perfusion scintigraphy for suspected pulmonary embolism
Metter DF, et al. AJR Am J Roentgenol 2017; 208(3): 489-494

"The optimal tracer for ventilation studies is Technegas, an ultra fine dispersion of 99mTc-labeled carbon. [...] Its main advantage is greater percentage deposition in the alveolar spaces and less undesirable adherence to the central airways, compared with droplet radioaerosols."