Klinische Ressourcen

Leitlinien

2009 EANM guidelines quoting Technegas

Die Europäische Vereinigung für Nuklearmedizin

EANM-Leitlinie zur Ventilations-/Perfusionsszintigraphie – Teil 1

Bajc M, et al. Eur J Nucl Med Mol Imaging 2009; 36: 1356-1370

EANM-Leitlinie zur Ventilations-/Perfusionsszintigraphie – Teil 2

Bajc M, et al. Eur J Nucl Med Mol Imaging 2009; 36: 1528-1538

Schulungen

Die funktionelle Lungenbildgebung mit TECHNEGASTM
Ventilationsszintigraphie mit SPECT/CT und TECHNEGASTM zur Quantifizierung der Lungenfunktion

Lungenstudien
Die Ventilations/Perfusions (V/P)-SPECT mit TECHNEGASTM zum Nachweis einer Lungenembolie

Zeugnis

Klinischer Nutzen über die Lungenembolie hinaus

Die Beurteilung von Ventilationsstörungen bei chronischen Atemwegserkrankungen
Die Aufnahmen wurden freundlicherweise zur Verfügung gestellt von Hunter New England Imaging am John Hunter Hospital; die klinischen Daten vom Hunter Medical Research Institute

Die Überwachung des Therapieansprechens bei Asthmapatienten
Die Aufnahmen und die klinischen Daten wurden freundlicherweise zur Verfügung gestellt vom Woolcock Institute of Medical Research

Die Evaluierung der Lungenfunktion vor einer chirurgischen Lungenvolumenreduktion
Die Aufnahmen wurden freundlicherweise zur Verfügung gestellt von Macquarie Medical Imaging; die klinischen Daten von Macquarie Respiratory and Sleep an der Macquarie-Universität.

Highlights aus der Literatur

Ausgabe 1 –Mai 2017
Die COPD:
Eine neue Indikation für V/Q-SPECT mit TECHNEGASTM?

Diese Ausgabe aufrufen

Ausgabe 3 –Oktober 2017
Der wirtschaftliche Wert der hybriden SPECT/CT in der Lungenemboliediagnostik

Diese Ausgabe aufrufen

Ausgabe 2 –August 2017
V/Q-SPECT/CT als Verfahren der Wahl zur Diagnostizierung einer Lungenembolie?

Diese Ausgabe aufrufen

Ausgabe 4 – Dezember 2018
Zusammenfassung des Berichts der Lancet-Kommission zur Neudefinition von Atemwegserkrankungen

Diese Ausgabe aufrufen

Klinische Literatur

Ventilation defect typical for COPD is frequent among patients suspected for pulmonary embolism but does not prevent the diagnosis of PE by V/P SPECT
Nasr A, et al. EC Pulmonology and Respiratory Medicine. 2017; 4(3): 85-91

"The introduction of the tomographic technique and the implementation of Technegas as a novel ventilation agent facilitated imaging of pulmonary embolism in comparison with planar imaging and particularly in COPD patients together with the new interpretation criteria."

Diagnosing and grading heart failure with tomographic perfusion lung scintigraphy: validation with right heart catheterization
Jögi J, et al. ESC Heart Fail 2018; 5(5): 902-910

"Although not as available as chest X-ray, V/P SPECT is a feasible alternative, especially because the introduction of SPECT and new ventilation tracers (i.e. Technegas) has lowered the number of non-diagnostic studies to <3%, even in the presence of obstructive lung disease."

CANM Guidelines for V/P SPECT in PE
Leblanc M, et al. CANM Guidelines published in November 2018

"The best widely available agent for ventilation is 99mTc-Technegas, an aerosol of carbon nanoparticles (5-200 nm) generated in a high temperature furnace (Technegas Generator, Cyclomedica). Because of the very small particle size, this agent is distributed in the lungs almost like a gas and deposited in alveoli by diffusion, where they remain stable, thus providing the best possible images for ventilation SPECT."

Lung scintigraphy in COPD
Mortensen J, et al. Semin Nucl Med 2019; 49(1): 16-21

"V/Q scintigraphy is a valuable functional imaging biomarker in relation to several aspects of COPD. Disturbances in the distribution of ventilation and perfusion, which are pertinent to the pathophysiology of COPD, are directly visualized, particularly when using inert gases or Technegas as ventilation tracers while performing the scintigraphy as SPECT."

Role of medical and molecular imaging in COPD
Myc LA, et al. Clin Transl Med 2019; 8(1): 12

"3D ventilation/perfusion SPECT imaging procedures have been used to help diagnosis. COPD patients have also been evaluated using Technegas (99mTc-labelled carbon particles). Technegas has the potential to provide valuable information for the diagnosis of COPD as it has been demonstrated to correlate positively with spirometric lung function."

SPECT Ventilation imaging in asthma
Farrow CE, et al. Semin Nucl Med 2019; 49(1): 11-15

"Technegas as a SPECT ventilation agent has a key advantage as it remains fixed after inhalation, which allows imaging of upright ventilation distribution, analogous of pulmonary function tests."

Identifying the heterogeneity of COPD by V/P SPECT: a new tool for improving the diagnosis of parenchymal defects and grading the severity of small airways disease
Bajc M, et al. Int J of Chron Obstruct Pulmon Dis 2017; 12: 1579-1587

"V/Q SPECT, using Technegas as the ventilation imaging agent, could diagnose and grade severity of COPD and also estimate preserved lung function in 94 patients. Moreover, V/Q SPECT appears to be a unique tool to reveal the heterogeneity of COPD caused by pulmonary comorbidities such as pulmonary embolism, left heart failure, lung tumor and pneumonia."

V/Q SPECT – Normal Values for Lobar Function and Comparison With CT Volumes
Bailey DL, et al. Semin Nucl Med 2019; 49(1): 58-61

"An advantage of using Technegas as the ventilation agent and radiolabelled macro-aggregated albumin microspheres as the perfusion agent is that the deposition pattern is fixed upon administration and thus different patient postures can be studied and the effect of gravity and position determined, even though the scans must be acquired with the subject supine using conventional gamma camera SPECT/CT systems"

Radionuclide diagnosis of pulmonary embolism
Hess S, et al. Adv Exp Med Biol 2017; 906: 49-65

"Technetium-99m (99mTc-Technegas) is widely available and relatively inexpensive while Xenon-133 is less than ideal for SPECT imaging owing to its relatively low energy and suboptimal spatial resolution."

Ventilation perfusion single photon emission computed tomography: Referral practices and diagnosis of acute pulmonary embolism in the quaternary clinical setting
Lawrence N, et al. J Med Imaging Radiat Oncol 2018; 62(6): 777-780

"However, the standard technique for V/Q SPECT in the US involves the use of Xenon radiotracer rather than Technegas rendering direct comparison of equivocal rates less useful."