Klinische Ressourcen


2009 EANM guidelines quoting Technegas

Die Europäische Vereinigung für Nuklearmedizin

EANM-Leitlinie zur Ventilations-/Perfusionsszintigraphie – Teil 1

Bajc M, et al. Eur J Nucl Med Mol Imaging 2009; 36: 1356-1370

EANM-Leitlinie zur Ventilations-/Perfusionsszintigraphie – Teil 2

Bajc M, et al. Eur J Nucl Med Mol Imaging 2009; 36: 1528-1538


Die funktionelle Lungenbildgebung mit Technegas™
Ventilationsszintigraphie mit SPECT/CT und Technegas™ zur Quantifizierung der Lungenfunktion

Die Ventilations/Perfusions (V/P)-SPECT mit Technegas™ zum Nachweis einer Lungenembolie


Klinischer Nutzen über die Lungenembolie hinaus

Die Beurteilung von Ventilationsstörungen bei chronischen Atemwegserkrankungen
Die Aufnahmen wurden freundlicherweise zur Verfügung gestellt von Hunter New England Imaging am John Hunter Hospital; die klinischen Daten vom Hunter Medical Research Institute

Die Überwachung des Therapieansprechens bei Asthmapatienten
Die Aufnahmen und die klinischen Daten wurden freundlicherweise zur Verfügung gestellt vom Woolcock Institute of Medical Research

Die Evaluierung der Lungenfunktion vor einer chirurgischen Lungenvolumenreduktion
Die Aufnahmen wurden freundlicherweise zur Verfügung gestellt von Macquarie Medical Imaging; die klinischen Daten von Macquarie Respiratory and Sleep an der Macquarie-Universität.

Highlights aus der Literatur

Ausgabe 1 –Mai 2017
Eine neue Indikation für V/Q-SPECT mit Technegas™?

Diese Ausgabe aufrufen

Ausgabe 3 –Oktober 2017
Der wirtschaftliche Wert der hybriden SPECT/CT in der Lungenemboliediagnostik

Diese Ausgabe aufrufen

Ausgabe 2 –August 2017
V/Q-SPECT/CT als Verfahren der Wahl zur Diagnostizierung einer Lungenembolie?

Diese Ausgabe aufrufen

Ausgabe 4 – Dezember 2018
Zusammenfassung des Berichts der Lancet-Kommission zur Neudefinition von Atemwegserkrankungen

Diese Ausgabe aufrufen

Klinische Literatur

SPECT Ventilation imaging in asthma
Farrow CE, et al. Semin Nucl Med 2019; 49(1): 11-15

"Technegas as a SPECT ventilation agent has a key advantage as it remains fixed after inhalation, which allows imaging of upright ventilation distribution, analogous of pulmonary function tests."

Identifying the heterogeneity of COPD by V/P SPECT: a new tool for improving the diagnosis of parenchymal defects and grading the severity of small airways disease
Bajc M, et al. Int J of Chron Obstruct Pulmon Dis 2017; 12: 1579-1587

"V/Q SPECT, using Technegas as the ventilation imaging agent, could diagnose and grade severity of COPD and also estimate preserved lung function in 94 patients. Moreover, V/Q SPECT appears to be a unique tool to reveal the heterogeneity of COPD caused by pulmonary comorbidities such as pulmonary embolism, left heart failure, lung tumor and pneumonia."

V/Q SPECT – Normal Values for Lobar Function and Comparison With CT Volumes
Bailey DL, et al. Semin Nucl Med 2019; 49(1): 58-61

"An advantage of using Technegas as the ventilation agent and radiolabelled macro-aggregated albumin microspheres as the perfusion agent is that the deposition pattern is fixed upon administration and thus different patient postures can be studied and the effect of gravity and position determined, even though the scans must be acquired with the subject supine using conventional gamma camera SPECT/CT systems"

Radionuclide diagnosis of pulmonary embolism
Hess S, et al. Adv Exp Med Biol 2017; 906: 49-65

"Technetium-99m (99mTc-Technegas) is widely available and relatively inexpensive while Xenon-133 is less than ideal for SPECT imaging owing to its relatively low energy and suboptimal spatial resolution."

Ventilation perfusion single photon emission computed tomography: Referral practices and diagnosis of acute pulmonary embolism in the quaternary clinical setting
Lawrence N, et al. J Med Imaging Radiat Oncol 2018; 62(6): 777-780

"However, the standard technique for V/Q SPECT in the US involves the use of Xenon radiotracer rather than Technegas rendering direct comparison of equivocal rates less useful."

Current status of ventilation-perfusion scintigraphy for suspected pulmonary embolism
Metter DF, et al. AJR Am J Roentgenol 2017; 208(3): 489-494

"The optimal tracer for ventilation studies is Technegas, an ultra fine dispersion of 99mTc-labeled carbon. [...] Its main advantage is greater percentage deposition in the alveolar spaces and less undesirable adherence to the central airways, compared with droplet radioaerosols."

Applications of Ventilation-Perfusion Scintigraphy in Surgical Management of Chronic Obstructive Lung Disease and Cancer
Tulchinsky M, et al. Semin Nucl Med 2017; 47(6): 671-679

"The best option for ventilation evaluation is aerosolized ultrafine 99mTc-labeled impregnated carbon particles (Technegas, Cyclopharm, Australia)."

Peripheral ventilation heterogeneity determines the extent of bronchoconstriction in asthma
Farrow CE, et al. J Appl Physiol (1985). 2017; 123(5): 1188-1194

"Ventilation SPECT imaging with Technegas was used as an estimation of regional ventilation [in asthma patients]."

Ventilation defect typical for COPD is frequent among patients suspected for pulmonary embolism but does not prevent the diagnosis of PE by V/P SPECT
Nasr A, et al. EC Pulmonology and Respiratory Medicine. 2017; 4(3): 85-91

"The introduction of the tomographic technique and the implementation of Technegas as a novel ventilation agent facilitated imaging of pulmonary embolism in comparison with planar imaging and particularly in COPD patients together with the new interpretation criteria."

Diagnosing and grading heart failure with tomographic perfusion lung scintigraphy: validation with right heart catheterization
Jögi J, et al. ESC Heart Fail 2018; 5(5): 902-910

"Although not as available as chest X-ray, V/P SPECT is a feasible alternative, especially because the introduction of SPECT and new ventilation tracers (i.e. Technegas) has lowered the number of non-diagnostic studies to <3%, even in the presence of obstructive lung disease."